Jada Pinkett Smith addressed the Oscars slap incident on Wednesday's "Red Table Talk."
Smith slapped Rock during the Oscars after he made a joke about Pinkett Smith's close-cropped haircut.
An actress with alopecia loses her hair.
A number of her guests have included the mother of 12-year-old Rio Allred, who died by suicide after being bullied.
"Think about what I've been through and what happened at the Oscars," Pinkett Smith said.
The moment is an opportunity for families with alopecia to share their experiences and explain what alopecia is.
Her husband and Rock were involved in an incident.
Will Smith and Chris Rock on stage at the Oscars in March.
"My deepest hope for Oscar night is that these two intelligent, capable men can heal, talk it out, and reconcile.
Today, we need both, and we need each other more than ever," she said.
"Until then, Will and I will keep doing what we've been doing for 28 years: figuring out life together. Thanks for listening."
Her husband publicly apologized to Rock and the Academy of Motion Picture Arts & Sciences after the incident.